Alfred Intensive Care Unit

Research Studies

Current ICU Research - Nov 2010

The POLAR Study

Does very early, sustained moderate hypothermia in patients with severe traumatic brain injury, increase favourable neurological outcomes? A randomised controlled trial.

 

 

EPO – TBI

Does erythropoetin alpha 40,000u s/c given once a week for 3 weeks or until ICU discharge, improve favourable neurological outcomes. A double blinded randomised controlled trial.

 

 

The ARISE Study

A multi centre, randomised controlled trial of early goal-directed therapy in patients presenting to the emergency department with severe sepsis in Australasia.

 

 

 

The Age of Blood Pilot Study

Feasibility of allocating the freshest available red blood cells to critically ill patients: a double blinded randomised controlled pilot study.

 

 

 

The Third International Study of Mechanical Ventilation.

A prospective, multicentre single cohort study of mechanical ventilation practices.

The SPICE Study

An observational study of sedation practices in intensive care.

The RIBFIX Study

A prospective randomised controlled trial of operative stabilisation of fractured ribs in trauma patients.

The Infinite Study

A registry of patients admitted to intensive care with serious or life-threatening illnesses related to Influenza A.

Sub-studies within Infinite:

  • Obstetric sub-study. An observational study that reports outcomes of pregnant and post-partum patients within the infinite registry.
  • The ECMO sub-study. An observational study of H1N1 patients who were treated with ECMO.

The Oesophageal Manometry Study

A pilot study that aims to establish whether oesophageal pressure readings can be a reliable reflection of transpleural pressure transmission in ventilated intensive care patients.

The SMAC Study

A study of staircase recruitment manoeuvres in ventilated patients with acute lung injury.

A Pressure Sore Study

A retrospective cohort study that aims to identify possible contributing factors to the development of pressure injuries in trauma patients in the intensive care unit.

The Melatonin Study

A randomised double blind placebo-controlled trial that aims to examine whether exogenous melatonin will improve sleep in ICU patients with sleep disturbances.

DAHLIA

A randomised, double-blind, multi-centre placebo controlled trial of dexmedetomidine for patients with agitation and delirium in the intensive care unit.

The STATINS Study

A phase ll randomised controlled trial of atorvastatin therapy in intensive care patients with severe sepsis.

PROWESS – Shock

A randomized, double-blind, placebo-controlled, multicenter, Phase 3 study of drorecogin alfa (activated) administered as a continuous 96-hour infusion to adult patients with septic shock.

The Adult Point Prevalence Program

A systematic program of point prevalence studies to facilitate ICU research in Australia and New Zealand by performing multiple observational point prevalence studies on a particular day.

 

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